암연구소 소개

연구실 소개

암 역학 연구실

Laboratory of Cancer Epidemiology
본 암 역학 연구실은 우리나라 사망 원인 1위인 암을 사전에 예방하고 관리함을 목적으로 하며 국내 연구뿐 아니라 국제 협력 연구를 활발히 진행 하고 있다. 연구 방법 및 대상 질환에 따라 박수경 교수가 이끄는 정밀의학/예방의학 연구실, 신애선 교수가 이끄는 만성병 역학 연구실, 최지엽 교수가 이끄는 시스템 역학 연구실로 나누어 구성되어 있다. 연구실 공간은 암연구소, 연구관, 의과학관에 위치하고 있으며 암 역학이라는 공통된 연구 주제를 바탕으로 연구 주제 발표회, 저널클럽, 북리딩 등의 연구활동이 활성화되어 있다.
참여 연구원
박수경

박수경 교수

  • 소속 : 예방의학교실
  • 전공 : 유전환경역학
  • 메일 : suepark@snu.ac.kr
신애선

신애선 교수

  • 소속 : 예방의학교실
  • 전공 : 역학
  • 메일 : shinaesun@snu.ac.kr
최지엽

최지엽 교수

  • 소속 : 의학과
  • 전공 : 분자유전체역학
  • 메일 : miso77@snu.ac.kr
연구내용


· 위암 발생과 연관된 위험인자 평가
· 갑상선암 발생 연관된 위험인자 평가 및 예후 관련 인자 확인
· 대장암 발생과 연관된 유전적, 환경적 위험요인 및 유전자-환경 상호작용 평가
· 역학적 연구방법을 적용한 기타 암 및 만성병 연구
· 환자-대조군 및 코호트의 대규모 일반 인구집단에서 암 및 만성질환의 발생을 예측하는 생체지표의 개발, 특히 생활습관 및 식이와 같은 환경적 요인에 따라 변화하는 개인의 감수성으로서 질병의 위험도 평가
· 유방암 및 암과 많은 공통 위험요인을 갖는 만성질환의 위험인자를 평가하는 역학 연구를 수행하며, 특히 신체활동과 약물치료에 의한 질병 발생 및 예후와 치료 성과에 대한 연구를 수행 중이다.

연구목표
본 연구실에서는 암 및 만성병의 발생 및 예후에 관여하는 다양한 환경적, 유전적 요인 또는 그의 상호작용을 복합적으로 연구하여 암 및 만성병의 발달기전 및 자연사에 미치는 영향을 설명하고자 한다. 또한 새로운 분석 방법론의 적용과 다양하고 정확한 환경요인을 측정하고자 분자 유전학적 생체지표를 발굴 및 평가하고 개인 및 집단의 환경 요인과 오믹스 정보를 통합한 역학 모델구축을 위한 연구를 계획하고 있다. 이외에도 인구집단에서 수정 가능한 요인인 신체 활동 및 좌식 활동의 정확하고 효율적인 측정 방법을 개발하고 측정된 활동에 의한 질병 발생 위험을 평가하고자 한다. 본 연구실은 개인별 맞춤 예방 시대를 맞이하여 암 및 만성병 예방을 위한 지침을 마련하고 적극적인 질병 예방을 실천하는 데 앞장서고자 한다.
연구성과
· Effect of citric acid cycle genetic variants and their interactions with obesity, physical activity and energy intake on the risk of colorectal cancer: Results from a nested case-control study in the UK biobank. Cho, S., Song, N., Choi, J. Y. & Shin, A., 2020, Cancers. 12, 10, p. 1-22 22 p., 2939.
· Plasma inflammatory biomarkers and modifiable lifestyle factors associated with colorectal cancer risk. Kim, J., Lee, J., Oh, J. H., Chang, H. J., Sohn, D. K., Shin, A. & Kim, J., 2020, Clinical Nutrition. 39, 9, p. 2778-2785 8 p.
· Associations among dietary seaweed intake, c-MYC rs6983267 polymorphism, and risk of colorectal cancer in a Korean population: a case–control study. Kim, J., Lee, J., Oh, J. H., Chang, H. J., Sohn, D. K., Shin, A. & Kim, J., 2020, European Journal of Nutrition. 59, 5, p. 1963-1974 12 p.
· Multi-grain rice diet decreases risk of breast cancer in Korean women: Results from the health examinees study. Shin, W. K., Lee, H. W., Shin, A., Lee, J. K., Lee, S. A., Lee, J. E. & Kang, D., 2020, Nutrients. 12, 8, p. 1-15 15 p., 2273.
· Efficacy of health coaching and a web-based program on physical activity, weight, and distress management among cancer survivors: A multi-centered randomised controlled trial. Yun, Y. H., Lim, C. I., Lee, E. S., Kim, Y. T., Shin, K. H., Kim, Y. W., Park, K. J., Jeong, S. Y., Ryu, K. W., Han, W., Jung, K. H., Park, S. C., Kim, M. S., Kim, S., Shim, Y. M., Oh, J. H., Lee, J. M., Ryoo, S. B., Woo, J., Noh, D. Y. & 13 others, , 2020, Psycho-Oncology. 29, 7, p. 1105-1114 10 p.
· Omega-3 and-6 Fatty Acid Intake and Colorectal Cancer Risk in Swedish Women's Lifestyle and Health Cohort. Shin, A., Cho, S., Sandin, S., Lof, M., Oh, M. Y. & Weiderpass, E., 2020, Cancer Research and Treatment. 52, 3, p. 848-854 7 p.
· Prognosis of Patients with Colorectal Cancer with Diabetes According to Medication Adherence: A Population-Based Cohort Study. Choe, S., Lee, J., Park, J. W., Jeong, S. Y., Cho, Y. M., Park, B. J. & Shin, A., 2020, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 29, 6, p. 1120-1127 8 p.
· Marital status and the prevalence of obesity in a Korean population. Lee, J., Shin, A., Cho, S., Choi, J. Y., Kang, D. & Lee, J. K., 2020, Obesity Research and Clinical Practice. 14, 3, p. 217-224 8 p.
· Optimal body mass index cut-off point for predicting colorectal cancer survival in an asian population: A national health information database analysis. Song, N., Huang, D., Jang, D., Kim, M. J., Jeong, S. Y., Shin, A. & Park, J. W., 2020, Cancers. 12, 4, 830.
· National cancer screening program for gastric cancer in Korea: Nationwide treatment benefit and cost. Suh, Y. S., Lee, J., Woo, H., Shin, D., Kong, S. H., Lee, H. J., Shin, A. & Yang, H. K., 2020, Cancer. 126, 9, p. 1929-1939 11 p.
· Acute High-Dose and Chronic Lifetime Exposure to Alcohol Consumption and Differentiated Thyroid Cancer: T-CALOS Korea. Hwang Y, Lee KE, Weiderpass E, Park YJ, Chai YJ, Kwon H, Park do J, Cho B, Choi HC, Kang D, Park SK. PLoS One. 2016 Mar 17; 11(3):e0151562.
· Diabetes Mellitusand Site-specific Colorectal Cancer Risk in Korea: A Case-control Study. Woo H, Lee J, Lee J, Park JW, Park S, Kim J, Oh JH, Shin A. J PrevMed Public Health. 2016 Jan; 49(1):45-52
· Annual Average Changes in Adult Obesity as a Risk Factor for Papillary Thyroid Cancer: A Large-Scale Case-Control Study. Hwang Y, Lee KE, Park YJ, Kim SJ, Kwon H, Park do J, Cho B, Choi HC, Kang D, Park SK. Medicine(Baltimore). 2016 Mar; 95(9):e2893.
· Impact of alcohol drinking on gastric cancer development according to Helicobacter pylori infection status. Ma SH, Jung W, Weiderpass E, Jang, Hwang Y, Ahn C, Ko KP, Chang SH, Shin HR, Yoo KY, Park SK. Br J Cancer. 2015 Nov 3; 113(9):1381-8.
· Radioactive Iodine Therapy Did Not Significantly Increase the Incidence and Recurrence of Subsequent Breast Cancer. Ahn HY, Min HS, Yeo Y, Ma SH, Hwang Y, An JH, Choi HS, Keam B, Im SA, Park DJ, Park IA, Noh DY, Youn YK, Chung JK, Cho BY, Park SK, Park YJ. J Clin Endocrinol Metab. 2015 Sep; 100(9):3486-93.
· Tumor subtype-specific associations of hormone-related reproductive factors on breast cancer survival. Song N, Choi JY, Sung H, Jeon S, Chung S, Song M, Park SK, Han W, Lee JW, Kim MK, Yoo KY, Ahn SH, Noh DY, Kang D. PLoS One. 2015 Apr 14; 10(4):e0123994.
· Prediction of breast cancer survival using clinical and genetic markers by tumor subtypes. Song N, Choi JY, Sung H, Jeon S, Chung S, Park SK, Han W, Lee JW, Kim MK, Lee JY, Yoo KY, Han BG, Ahn SH, Noh DY, Kang D. PLoS One. 2015 Apr 13; 10(4):e0122413.
· Heterogeneity of epidemiological factors by breast tumor subtypes in Korean women: a case-case study. Song N, Choi JY, Sung H, Chung S, Song M, Park SK, Han W, Lee JW, Kim MK, Yoo KY, Ahn SH, Noh DY, Kang D. Int J Cancer. 2014 Aug 1; 135(3):669-81.
· The associations between immunity-related genes and breast cancer prognosis in Korean women. Choi J, Song N, Han S, Chung S, Sung H, Lee JY, Jung S, Park SK, Yoo KY, Han W, Lee JW, Noh DY, Kang D, Choi JY. PLoS One. 2014 Jul 30; 9(7):e103593.
· 2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy. Li J, Lindström LS, Foo JN, Rafiq S, Schmidt MK, Pharoah PD, Michailidou K,Dennis J, Bolla MK, Wang Q, Van 't Veer LJ, Cornelissen S, Rutgers E, Southey MC, Apicella C, Dite GS, Hopper JL, Fasching PA, Haeberle L, Ekici AB, Beckmann MW, Blomqvist C, Muranen TA, Aittomäki K, Lindblom A, Margolin S, Mannermaa A, Kosma VM, Hartikainen JM, Kataja V, Chenevix-Trench G; kConFab Investigators., Phillips KA, McLachlan SA, Lambrechts D, Thienpont B, Smeets A, Wildiers H, Chang-Claude J, Flesch-Janys D, Seibold P, Rudolph A, Giles GG, Baglietto L, Severi G, Haiman CA, Henderson BE, Schumacher F, LeMarchand L, Kristensen V, Alnæs GI, Borresen-Dale AL, Nord S, Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M, Andrulis IL, Knight JA, Glendon G, Tchatchou S, Devilee P, Tollenaar R, Seynaeve C, Hooning M, Kriege M, Hollestelle A, van den Ouweland A, Li Y, Hamann U, Torres D, Ulmer HU, Rüdiger T, Shen CY, Hsiung CN, Wu PE, Chen ST, Teo SH, Taib NA, Har Yip C, Fuang Ho G, Matsuo K, Ito H, Iwata H, Tajima K, Kang D, Choi JY, Park SK, Yoo KY, Maishman T, Tapper WJ, Dunning A, Shah M, Luben R, Brown J, Khor CC, Eccles DM, Nevanlinna H, Easton D, Humphreys K, Liu J, Hall P, Czene K. Nat Commun. 2014 Jun 17; 5:4051.
· A systematic review and meta-analysis of effects of menopausal hormone therapy on cardiovascular diseases. Ji-Eun Kim, Jae-Hyuck Chang, Min-Ji Jeong, Jaesung Choi, JooYong Park, Chaewon Baek, Aesun Shin, Sang Min Park, Daehee Kang, Ji-Yeob Choi. Scientific Reports 2020 accepted
· Patterns of leisure time and household physical activity and the risk of mortality among middle-aged Korean adults. JooYong Park, Ji-Yeob Choi, Aesun Shin, Sang-Ah Lee, Miyoung Lee, Jaesung Choi, Jong-koo Lee, Daehee Kang. 2020; PloS one 15 (6), e0234852
· Relative effects of demographic, psychological, behavioral, and social factors on the initiation and maintenance of leisure-time physical activity: Results from a confirmatory path analysis in a longitudinal study. J Choi, JY Park, JE Kim, J Lee, D Kang, M Lee, IJ Chung, JY Choi. Journal of Epidemiology, 2020; JE20200073
· Trends and Correlates of High-Risk Alcohol Consumption and Types of Alcoholic Beverages in Middle-Aged Korean Adults: Results From the HEXA-G Study. Jaesung Choi, Ji-Yeob Choi, Aesun Shin, Sang-Ah Lee, Kyoung-Mu Lee, Juhwan Oh, Joo Yong Park, Jong-Koo Lee, Daehee Kang. 2019; J Epidemiol. 2019 Apr 5;29(4):125-132.
· Altered expression of fucosylation pathway genes is associated with poor prognosis and tumor metastasis in non small cell lung cancer. Soonbum Park, Jin Muk Lim, Jung Nyeo Chun, Sanghoon Lee, Tae Min Kim, Dong Wan Kim, Sang Yeob Kim, Dong Jun Bae, Sang Mun Bae, Insuk So, Hong Gee Kim, Ji Yeob Choi, Ju Hong Jeon. International journal of oncology 2020; 56 (2), 559-567
· Association between family history of diabetes and clusters of adherence to healthy behaviors: cross-sectional results from the Health Examinees-Gem study (HEXA-G). Choi J, Choi JY, Lee SA, Lee KM, Shin A, Oh J, Park JY, Song M, Yang JJ, Lee Jk, Kang D. BMJ Open, 2019; 9(6):e025477
· Associations of postmenopausal hormone therapy with metabolic syndrome among diabetic and non-diabetic women. Kim JE, Choi J, Park JY, Lee J, Shin A, Park SM, Kang D, Choi JY. Maturitas, 2019; 121:76-82
· Prevalence of Participating in Physical Activity From 2 Korean Surveillance Systems: KNHANES and KCHS. Park JY, Shin A, Lee M, Choi J, Song M, Kim Y, Lee Jk, Kang D, Choi JY. J Phy Act Health, 2018; 15(10): 763-773
· Trend and correlates of the high-risk alcohol consumption and type of alcoholic beverage in Korean middle-aged adults: Results from the HEXA-G study. Choi J, Choi JY, Shin A, Lee SA, Lee KM, Oh J, Park JY, Lee Jk, Kang D. J Epidemiol, 2018; JE20170296
· Associations between genetic polymorphisms of membrane transporter genes and prognosis after chemotherapy: meta-analysis and finding from Seoul Breast Cancer Study (SEBCS). Kim JE, Choi J, Park JY, Park C, Lee SM, Park SE, Song N, Chung S, Sung H, Han W, Lee JW, Park SK, Kim MK, Noh DY, Yoo KY, Kang D, Choi JY. Pharmacogenomics J, 2018; 18:633-645
· Correlates associated with participation in physical activity among adults: a systematic review of reviews and update. Choi J, Lee M, Lee J, Kang D, Choi JY. BMC Public Health. 2017 Apr;17(1):356 doi: 10.1186/s12889-017-4255-2.PMID: 28438146
· Genetic Predisposition of Polymorphisms in HMGB1-Related Genes to Breast Cancer Prognosis in Korean Women. Lee J, Choi J, Chung S, Park J, Kim JE, Sung H, Han W, Lee JW, Park SK, Kim MK, Ahn SH, Noh DY, Yoo KY, Kang D, Choi JY. J Breast Cancer. 2017 Mar;20(1):27-34. doi: 10.4048/jbc.2017.20.1.27. Epub 2017 Mar 24. PubMed PMID: 28382092
· Sim EJ, Ko KP, Ahn C, Park SM, Surh YJ, An S, Kim SW, Lee MH, Lee JW, Lee JE, Kim KS, Yom CK, Kim HA, Park SK. Isoflavone intake on the risk of overall breast cancer and molecular subtypes in women at high risk for hereditary breast cancer. Breast Cancer Res Treat. 2020 Nov;184(2):615-626. doi: 10.1007/s10549-020-05875-0. Epub 2020 Oct 17. PMID: 33068197.
· Yoo JY, Cho HJ, Moon S, Choi J, Lee S, Ahn C, Yoo KY, Kim I, Ko KP, Lee JE, Park SK. Pickled Vegetable and Salted Fish Intake and the Risk of Gastric Cancer: Two Prospective Cohort Studies and a Meta-Analysis. Cancers (Basel). 2020 Apr 17;12(4):996. doi: 10.3390/cancers12040996. PMID: 32316595; PMCID: PMC7225928.
· Ahn C, Lee S, Park SK. Causal Inference between Rheumatoid Arthritis and Breast Cancer in East Asian and European Population: A Two-Sample Mendelian Randomization. Cancers (Basel). 2020 Nov 5;12(11):E3272. doi: 10.3390/cancers12113272. PMID: 33167385
구성원
성명 소속 직급
박수경 서울대학교 의과대학 예방의학교실 교수
신애선 서울대학교 의과대학 예방의학교실 교수
조수영 서울대학교 의과대학 예방의학교실 박사 과정
황퉁 서울대학교 의과대학 예방의학교실 박사 과정
나현탁 서울대학교 암연구소 석사 과정
서승희 서울대학교 암연구소 석사 과정
유수민 서울대학교 의과대학 예방의학교실 석사 과정
최지엽 서울대학교 의과대학 대학원 부교수
최재성 서울대학교 의료관리학연구소 연수연구원
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