본 연구실에서 만성감염 병원성 기전을 규명하는 과정에서 도출된 병원성 변이주, 균주 다양성, 유전체 변이 등을 응용하여 임상적으로 유용하게 사용될 수 있는 면역항암치료제, 결핵 생백신 및 B형간염바이러스 (HBV) 치료용 백신 등을 개발하고자 한다.

Potential Use of Mycobacterium paragordonae for Antimycobacterial Drug Screening Systems. Cha GY, Seo H, Oh J, Kim BJ, Kim BJ. 31 Jan 2023 J Microbiol. 61, 121–129 (2023).
Global prevalence and molecular characteristics of three clades within hepatitis B virus subgenotype C2: Predominance of the C2(3) clade in South Korea. Kim DH, Choi YM, Jang J, Kim BJ. 9 Mar 2023 Front Microbiol.14:1137084.
Locked nucleic acid real-time polymerase chain reaction method identifying two polymorphisms of hepatitis B virus genotype C2 infections, rt269L and rt269I. Kim K, Choi YM, Kim DH, Jang J, Choe WH, Kim BJ. 21 Mar 2023 World J Gastroenterol. 29(11):1721-1734.
rt269L-Type hepatitis B virus (HBV) in genotype C infection leads to improved mitochondrial dynamics via the PERK-eIF2α-ATF4 axis in an HBx protein-dependent manner. 30 Mar 2023. Cell Mol Biol Lett. 28(1):26.
Live Mycobacterium paragordonae induces heterologous immunity of natural killer cells by eliciting type I interferons from dendritic cells via STING-dependent sensing of cyclic-di-GMP. Lee MH, Kim BR, Seo H, Oh JH, Kim HL, Kim BJ. Apr 2023. Microbes Infect. 27:105144.
Potential of Mycobacterium tuberculosis chorismate mutase (Rv1885c) as a novel TLR4-mediated adjuvant for dendritic cell-based cancer immunotherapy. Jeong H, Lee SY, Seo H, Kim DH, Lee D, Kim BJ. 20 Jan 2022. Oncoimmunology. 11(1):2023340.
A Novel DNA Vaccine Against SARS-CoV-2 Encoding a Chimeric Protein of Its Receptor-Binding Domain (RBD) Fused to the Amino-Terminal Region of Hepatitis B Virus preS1 With a W4P Mutation. Jeong H, Choi YM, Seo H, Kim BJ. 26 Feb 2021. Front Immunol.12:637654.
rt269I Type of Hepatitis B Virus (HBV) Polymerase versus rt269L Is More Prone to Mutations within HBV Genome in Chronic Patients Infected with Genotype C2: Evidence from Analysis of Full HBV Genotype C2 Genome. Jeong H, Kim DH, Choi YM, Choi H, Kim D, Kim BJ. 15 Mar 2021. Microorganisms. 9(3):601.
Recombinant Mycobacterium smegmatis delivering a fusion protein of human macrophage migration inhibitory factor (MIF) and IL-7 exerts an anticancer effect by inducing an immune response against MIF in a tumor-bearing mouse model. Jeong H, Lee SY, Seo H, Kim BJ. Aug 2021. J Immunother Cancer. 9(8):e003180.
Recombinant Mycobacterium paragordonae Expressing SARS-CoV-2 Receptor-Binding Domain as a Vaccine Candidate Against SARS-CoV-2 Infections. Kim BJ, Jeong H, Seo H, Lee MH, Shin HM, Kim BJ. Front Immunol. 27 Aug 2021. 12:712274.