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암연구소 소개

연구실 소개

발암기전 및 화학암예방 연구실

Laboratory of Molecular Carcinogenesis and Chemoprevention
본 연구실은 1996년 서영준 교수가 부임하면서 최초 설립되었으며, 2004년 당시 과학기술부의 지원을 받는 국가지정 연구실과 이후 교과부 우수학자 사업에 선정되었다. 2011년에는 한국연구재단지정 종양미세환경 글로벌핵심 연구센터 사업단을 맡아 암과 주변세포와의 유기적 네트워킹을 집중적으로 분석하는 연구를 수행하고 있다. 특히 염증 및 면역세포와 암세포의 상호작용이 종양의 진행에 미치는 영향과 이를 억제하는 천연화합물을 발굴하고 그 분자세포생물학적 작용기전 규명에 관한 연구에 집중하고 있다
참여 연구원
연구내용

본 연구실에서는 암화과정을 촉진하는 염증미세환경을 조절하는 세포내 신호전달 물질을 표적으로 하는 화학적 암예방 연구와 염증과 관련된 산화적 스트레스에 대한 생체방어 기전에 관심을 갖고 있다. 궁극적으로 염증의 신호전달 네트워크를 중심으로 암화과정에서 비정상적으로 활성화되어 있는 염증성 신호전달 물질이나 이들의 유전자 발현에 관련된 전사인자들을 탐구하고 있다. 그간 수행한 연구로 Nature Reviews Cancer, Journal of National Cancer Institute, Cancer Research (6), Oncogene (3), Cancer Letters (17)를 포함한 SCI 저널에 350편이상의 논문을 발표하였다(총 피인용 횟수, 26,000회; H-Index, 83). 이러한 연구 업적을 바탕으로 연구책임자인 서영준 교수는 이달의 과학기술자상(2006), 지식창조대상(2011), 한국과학상(2013), 인촌상(2015), 한독학술대상(2020)을 수상하였다.

연구목표
종양미세환경에서 암세포와 대식세포 및 섬유아세포등 주변의 기질 세포들과의 상호작용에 관여하는 새로운 신호전달 물질들을 발굴하고 이들의 작용기전을 규명하고자 한다.
연구성과
- Kim SH, Saeidi S, Zhong X, Gwak SY, Muna IA, Park SA, Kim SH, Na HK, Joe Y, Chung HT, Kim KE, Han W, Surh YJ. Breast cancer cell debris diminishes therapeutic efficacy through heme oxygenase-1-mediated inactivation of M1-like tumor-associated macrophages. Neoplasia. 2020 Nov;22(11):606-16.
- Piao JY, Kim SJ, Kim DH, Park JH, Park SA, Han HJ, Na HK, Yoon K, Lee HN, Kim N, Hahm KB, Surh YJ. Helicobacter pylori infection induces STAT3 phosphorylation on Ser727 and autophagy in human gastric epithelial cells and mouse stomach. Sci Rep. 2020 Sep 24;10(1):15711.
- Park SA, Sung NJ, Choi BJ, Kim W, Kim SH, Surh YJ. Gremlin-1 augments the oestrogen-related receptor α signalling through EGFR activation: implications for the progression of breast cancer. Br J Cancer. 2020 Sep;123(6):988-99.
- Suh J, Kim DH, Lee YH, Jang JH, Surh YJ. Fibroblast growth factor-2, derived from cancer-associated fibroblasts, stimulates growth and progression of human breast cancer cells via FGFR1 signaling. Mol Carcinog. 2020 Sep;59(9):1028-40.
- Kim S, Kim W, Kim DH, Jang JH, Kim SJ, Park SA, Hahn H, Han BW, Na HK, Chun KS, Choi BY, Surh YJ. Resveratrol suppresses gastric cancer cell proliferation and survival through inhibition of PIM-1 kinase activity. Arch Biochem Biophys. 2020 Aug 15;689:108413.
- Shin JW, Chun KS, Kim DH, Kim SJ, Kim SH, Cho NC, Na HK, Surh YJ. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification. Biochem Pharmacol. 2020 Mar;173:113820.
- Jang JH, Kim DH, Lim JM, Lee JW, Jeong SJ, Kim KP, Surh YJ. Breast Cancer Cell-Derived Soluble CD44 Promotes Tumor Progression by Triggering Macrophage IL1β Production. Cancer Res. 2020 Mar 15;80(6):1342-56.
- Kim DH, Jang JH, Kwon OS, Cha HJ, Youn HJ, Chun KS, Surh YJ. Nuclear Factor Erythroid-Derived 2-Like 2-Induced Reductive Stress Favors Self-Renewal of Breast Cancer Stem-Like Cells via the FoxO3a-Bmi-1 Axis. Antioxid Redox Signal. 2020 Jun;32(18):1313-29.
- Jamil MU, Kim J, Yum HW, Kim SH, Kim SJ, Kim DH, Cho NC, Na HK, Surh YJ. 17-Oxo-docosahexaenoic acid induces Nrf2-mediated expression of heme oxygenase-1 in mouse skin in vivo and in cultured murine epidermal cells. Arch Biochem Biophys. 2020 Jan 15;679:108156.
- Lee EJ, Kim SJ, Hahn YI, Yoon HJ, Han B, Kim K, Lee S, Kim KP, Suh YG, Na HK, Surh YJ. 15-Keto prostaglandin E 2 suppresses STAT3 signaling and inhibits breast cancer cell growth and progression. Redox Biol. 2019 May;23:101175.
- Paik JY, Lee HG, Piao JY, Kim SJ, Kim DH, Na HK, Surh YJ. Helicobacter pylori infection promotes autophagy through Nrf2-mediated heme oxygenase upregulation in human gastric cancer cells. Biochem Pharmacol. 2019 Apr;162:89-97.
- Yoon HJ, Kim DH, Kim SJ, Jang JH, Surh YJ. Src-mediated phosphorylation, ubiquitination and degradation of Caveolin-1 promotes breast cancer cell stemness. Cancer Lett. 2019 May 1;449:8-19.
- Lee YH, Song NY, Suh J, Kim DH, Kim W, Ann J, Lee J, Baek JH, Na HK, Surh YJ. Curcumin suppresses oncogenicity of human colon cancer cells by covalently modifying the cysteine 67 residue of SIRT1. Cancer Lett. 2018 Sep 1;431:219-229.
- Zhong X, Lee HN, Kim SH, Park SA, Kim W, Cha YN, Surh YJ. Myc-nick promotes efferocytosis through M2 macrophage polarization during resolution of inflammation. FASEB J. 2018 Oct;32(10):5312-25.
- Hahn YI, Kim SJ, Choi BY, Cho KC, Bandu R, Kim KP, Kim DH, Kim W, Park JS, Han BW, Lee J, Na HK, Cha YN, Surh YJ. Curcumin interacts directly with the Cysteine 259 residue of STAT3 and induces apoptosis in H-Ras transformed human mammary epithelial cells. Sci Rep. 2018 Apr 23;8(1):6409.
- Suh J, Kim DH, Kim EH, Park SA, Park JM, Jang JH, Kim SJ, Na HK, Kim ND, Kim NJ, Suh YG, Surh YJ. 15-Deoxy-Δ 12,14-prostaglandin J 2 activates PI3K-Akt signaling in human breast cancer cells through covalent modification of the tumor suppressor PTEN at cysteine 136. Cancer Lett. 2018 Jun 28;424:30-45.
- Suh J, Kim DH, Surh YJ. Resveratrol suppresses migration, invasion and stemness of human breast cancer cells by interfering with tumor-stromal cross-talk. Arch Biochem Biophys. 2018 Apr 2;643:62-71.
- Song NY, Lee YH, Na HK, Baek JH, Surh YJ. Leptin induces SIRT1 expression through activation of NF-E2-related factor 2: Implications for obesity-associated colon carcinogenesis. Biochem Pharmacol. 2018 Jul;153:282-91.
- Kim SH, Zhong X, Kim W, Kim K, Suh YG, Kim C, Joe Y, Chung HT, Cha YN, Surh YJ. Taurine chloramine potentiates phagocytic activity of peritoneal macrophages through up-regulation of dectin-1 mediated by heme oxygenase-1-derived carbon monoxide. FASEB J. 2018 Apr;32(4):2246-57.
- Choi BJ, Park SA, Lee SY, Cha YN, Surh YJ. Hypoxia induces epithelial-mesenchymal transition in colorectal cancer cells through ubiquitin-specific protease 47-mediated stabilization of Snail: A potential role of Sox9. Sci Rep. 2017 Nov 21;7(1):15918.
Yum HW, Park J, Park HJ, Shin JW, Cho YY, Kim SJ, Kang JX, Surh YJ. Endogenous ω-3 Fatty Acid Production by fat-1 Transgene and Topically Applied Docosahexaenoic Acid Protect against UVB-induced Mouse Skin Carcinogenesis. Sci Rep. 2017 Sep 14;7(1):11658.
- Ngo HKC, Kim DH, Cha YN, Na HK, Surh YJ. Nrf2 Mutagenic Activation Drives Hepatocarcinogenesis. Cancer Res. 2017 Sep 15;77(18):4797-808.
- Park SA, Surh YJ. Modulation of tumor microenvironment by chemopreventive natural products. Ann NY Acad Sci. 2017 Aug;1401(1):65-74.
- Kim W, Lee HN, Jang JH, Kim SH, Lee YH, Hahn YI, Ngo HK, Choi Y, Joe Y, Chung HT, Chen Y, Cha YN, Surh YJ. 15-Deoxy-Δ 12,14-Prostaglandin J 2 Exerts Proresolving Effects Through Nuclear Factor E2-Related Factor 2-Induced Expression of CD36 and Heme Oxygenase-1. Antioxid Redox Signal. 2017 Dec 10;27(17):1412-31.
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성명 소속 직급
김수정 서울대학교 종합약학연구소 연구교수
Soma Saeeidi 서울대학교 종합약학연구소 박사후 연구원
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