Overview
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Overview
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Laboratory Introduction
Laboratory Introduction
Macrophage Laboratory
Macrophage Laboratory
Macrophage Laboratory studies the biological role of macrophage, an innate immune cell that distinguishes and removes foreign substances from the front of the body while recovering damaged tissues. In particular, the goal of our lab is to identify and control pathological macrophage sub-types associated with various diseases (cancer, inflammation) through multidisciplinary research with medical sciences to find ways to help treat diseases. The researchers are composed of senior researcher, a professor of Microbiology and Immunology at Seoul National University College of Medicine, Seok Seung-Hyeok, a professor of Transdisciplinary Department of Medicine and Advanced Technology at Seoul National University Hospital, Na Yi-Rang, Post-doctoral researcher Jung Hye-Won, researcher Lee Ji-eun, researcher Han Seung-hee, and MS/PhD candidate students.
Related Researcher
Seung Hyeok Seok Professor
- Email : lamseok@snu.ac.kr
Research topics
1. Development of Cancer Immunotherapeutic Treatment by Targeting Tumor Associated Macrophage Macrophage, which makes up the large part of tumor, suppresses the function of CD8 T cells, greatly inhibiting the effectiveness of the immune checkpoint blockers currently in use. In our lab, we explore how tumor associated macrophage suppresses CD8 T cells and develop a new booster-concept cancer immunotherapeutic drug that can maximize the effectiveness of existing treatments by converting M2 type macrophage to M1 type. To this end, we introduce a variety of transgenic mice, and at the same time, we aim for applicable pre-clinical research through efficient convergence with clinical studies.
2. Development of a Method for Improving Tissue Regeneration by Macropage Cell Therapy The regeneration of mucosal layers in Inflammatory Bowel Disease is a prerequisite for complete resolution. By using the great potential of macrophage in a process of tissue regeneration, our lab are trying to develop Macrophage Cell Therapy for many regenerative diseases .
Research goals
Research achievements
1) Circulation Time-Optimized Albumin Nano platform for Quantitative Visualization of Lung Metastasis via Targeting of Macrophages. Chung H, Park JY, Kim K, Yoo RJ, Suh M, Gu GJ, Kim JS, Choi TH, Byun JW, Ju YW, Han W, Ryu HS, Chung G, Hwang DW, Kim Y, Kang HR, Na YR, Choi H, Im HJ, Lee YS, *, Seok SH*. ACS Nano. (IF 18.027).
2) Prostaglandin E2 Receptor PTGER4-expressing macrophages promote intestinal epithelial barrier regeneration upon inflammation. Na YR, Jung D, Stakenborg M, Jang H, Gu GJ, Jeong MR, Suh SY, Kim HJ, Kwon YH, Sung TS, Ryoo SB, Park KJ, Im JP, Lee YS, Han H, Park B, Lee S, Kim D, Lee HS, Cleynen I, Matteoli G*, Seok SH*. Gut. 2021. (IF 23.059).
3) Macrophages-triggered sequential remodeling of endothelium-interstitial matrix to form pre-metastatic niche in microfluidic tumor microenvironment. Kim H, Chung H, Kim J, Choi DH, ShinY, KangYG, KimBM, SeoSU, Chung S*, Seok SH*. Advanced Science. 2019. (IF 16.806).
4) Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD. Na YR, Stakenborg M, Seok SH*,MatteoliG*. Nature Reviews Gastroenterology & Hepatology.2019 (IF 46.802).
5) Protein Kinase A Catalytic Subunit Is a Molecular Switch that Promotes the Pro-tumoral Function of Macrophages. Na YR, Kwon JW, Kim DY, Chung H, Song J, Jung D, Quan H, Kim D, Kim JS, Ju YW, Han W, Ryu HS, Lee YS, Hong JJ, Seok SH. Cell Rep. 2020. (IF 9.423).
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