Overview
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Overview
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Laboratory Introduction
Laboratory Introduction
Laboratory of Veterinary Pathology
Laboratory of Veterinary Pathology
Our laboratory was established in 1995 and consists of professor, graduate student and postdoctal researcher. Our lab provides rapid and accurate diagnositc pathology service for local practitioners, animal teaching hospital and zoos. Our lab also provide toxicity test evaluation as well as evaluating the efficacy of animal studies. In addition, our lab perform various translational researchs on human cancer and chronic inflammatory diseases (atherosclerosis or asthma) using appropriate animal models.
Related Researcher
Dae-Yong Kim Professor
- Email : daeyong@snu.ac.kr
Research topics
1. Perform diagnostic pathology service of all animal species and provide proper and accurate preventive measure or treatment guideline.
2. Perform pathology evaluation of safety test inculding carcinogenesis test as well as efficacy of new drug or therapeutic candidate using in vivo study.
3. Develop and establish better translational animal models for studying human cancer and chronic inflammatory diseases (genetically modified mouse or organoid)
4. Study carcinogenesis using animal model.
2. Perform pathology evaluation of safety test inculding carcinogenesis test as well as efficacy of new drug or therapeutic candidate using in vivo study.
3. Develop and establish better translational animal models for studying human cancer and chronic inflammatory diseases (genetically modified mouse or organoid)
4. Study carcinogenesis using animal model.
Research goals
1. Establishment of more rapid and accurate animal diagnostic pathology system.
2. Devlopment and establishment of mouse knock out model and organoid for studying human cancer.
3. Development of better humanized animal model
Research achievements
An W, Yang H, Yang E, Chung SY, Kim DY, Jou IL, Park SM, Kim BG, Chwae YJ, Joe EH (2021) Dying neurons conduct repair processes in the injured brain through osteopontin expression in cooperation with infiltrated blood monocytes. Glia. 69(4):1037-1052.
Go DM, Lee SH, Lee SH, Woo SH, Kim KD, Park KS, Park JH, Ha SJ, Kim WH, Choi JH, Kim DY (2021). Regulation of Helicobacter-induced gastritis by programmed death ligand 1-expressing classical dendritic cells. Cell and Molecular Gastroenterology and Hepatology 12:715-739.
An HW, Kim SY, Kwon JW, Seok SH, Woo SH, Kim DY, Park JW (2021) A In Vivo CRISPR-Cas9 Knockout Screening Using Quantitative PCR Identifies Thymosin Beta 4 X-Linked that Promotes Diffuse-Type Gastric Cancer Metastasis. Molecular Carcinogenesis 60:597-606.
Lee SH, Kim NY, Kim MK, Woo SH, Han IH, Kim GD, Park KS, Kim KB, Shim DH, Park SE, Park JS, Go DM, Kim DY, Yoon WK, Lee SP, Cheong JS, Kim KW, Park JH, Lee SH, See S, Ann SJ, Lee SH, Oh GT, Park WY, Lee HO, Choi JH (2022) Identification of PPARr as a key regulator of hyperlipemia-induced aortic valve inflammation via single cell transcriptome analysis. Nature Communication 13:5461
An HW, Seok SH, Kwon JW, Choudhury AD, Oh JS, Voon DC, Kim DY, Park JW (2022). The loss of epithelial Smad4 drives immune evasion via CXCL1 while displaying a vulnerability to combinatorial immune checkpoint blockade in gastric cancer Cell Reports 41:111878
Woo SH, Kyung DS, Lee SH, Park KS, Kim MK, Kim KB, Kwon HJ, Won YS, Choi IP, Park YJ, Go DM, Oh JS, Yoon WK, Paik SS, Kim JH, Kim YH, Choi JH, Kim DY (2023) TXNIP attenuates atherosclerotic calcification via suppressing the osteochondrogenic phenotypic switch of vascular smooth muscle cell. Circulation Research 132:52-71
Kwon JW, Seok SH, Kim SM, An HW, Choudhury AD, Woo SH, Oh JS, Kim JK, Voon DC, Kim DY, Park JW (2023) A synergistic partnership between IL-33/ST2 and Wnt pathway through Bcl-xL drives gastric cancer stemness and metastasis. Oncogene 42:501-515
Lee NY, Kim DY, Kim YJ, Kim DY (2023) Splenic epithelial cyst in a dog. Journal of Veterinary Diagnostic Investigation 35:209-211
Oh JS, Lee NY, Kim DY, Yoon SH (2023) The primary hepatic well differentiated liposarcoma in a meerkat (Suricata suricatta) Journal of Veterinary Medical Sciences (accepted)
Lee SY, Park HH, Oh JS, Byun KB, Kim DY, Yun HK, Kang BJ (2023). Hydroxyapatite microbeads containingBMP-2 and quercetin fabricated via electrostatic spraying to encourage bone regeneration. Biomedical Engineering Online 22:15
An HW, Seok SH, Kwon JW, Choudhury AD, Oh JS, Voon DC, Kim DY, Park JW (2022). The loss of epithelial Smad4 drives immune evasion via CXCL1 while displaying a vulnerability to combinatorial immune checkpoint blockade in gastric cancer Cell Reports 41:111878
Woo SH, Kyung DS, Lee SH, Park KS, Kim MK, Kim KB, Kwon HJ, Won YS, Choi IP, Park YJ, Go DM, Oh JS, Yoon WK, Paik SS, Kim JH, Kim YH, Choi JH, Kim DY (2023) TXNIP attenuates atherosclerotic calcification via suppressing the osteochondrogenic phenotypic switch of vascular smooth muscle cell. Circulation Research 132:52-71
Kwon JW, Seok SH, Kim SM, An HW, Choudhury AD, Woo SH, Oh JS, Kim JK, Voon DC, Kim DY, Park JW (2023) A synergistic partnership between IL-33/ST2 and Wnt pathway through Bcl-xL drives gastric cancer stemness and metastasis. Oncogene 42:501-515
Lee NY, Kim DY, Kim YJ, Kim DY (2023) Splenic epithelial cyst in a dog. Journal of Veterinary Diagnostic Investigation 35:209-211
Oh JS, Lee NY, Kim DY, Yoon SH (2023) The primary hepatic well differentiated liposarcoma in a meerkat (Suricata suricatta) Journal of Veterinary Medical Sciences (accepted)
Lee SY, Park HH, Oh JS, Byun KB, Kim DY, Yun HK, Kang BJ (2023). Hydroxyapatite microbeads containingBMP-2 and quercetin fabricated via electrostatic spraying to encourage bone regeneration. Biomedical Engineering Online 22:15