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Overview

Laboratory Introduction

Laboratory of Autoimmunity

Laboratory of Autoimmunity
Related Researcher
이은영

Eun Young Lee Professor

Research topics

Research goals
신규 치료 타겟 및 바이오마커를 발굴하고 실제 치료에 적용하기 위해 염증성 근염 (피부근염/다발성근염) 근육조직과 혈청 샘플 에서 대사체 프로파일링 분석을 통한 바이오마커 개발, 신규타깃 디스커버리를 계획하고 있습니다. 또한, 단일 세포 유전체 분석과 후성유전체 연구를 융합하여 다양한 희귀면역질환 및 생물학적 제재 치료 시 면역세포 간의 다양한 상호작용과 변화를 밝히고자 합니다. 연구 결과를 바탕으로 병인 기전에 관여하는 주된 세포 구성을 밝혀내고, 이를 선제적 치료에 적용하고자 합니다.
Research achievements
  • Kim JY, Kang YC, Kim MJ, Kim SU, Kang HR, Yeo JS, Kim Y, Yu SH, Song B, Hwang JW, Lee YS, Byun JW, Yoo DH, Kim HS, Han K, Kim CH, Lee EY. Mitochondrial transplantation as a novel therapeutic approach in idiopathic inflammatory myopathy. Ann Rheum Dis, 2025 Jan31: S0003-4967(25)00070-6. 
  • Chang SH, Park YB, McDermott GC, Paudel ML, Hayashi K, Ha YJ, Lee JS, Kim MU, Park CH, Kim JW, Ha JW, Chung SW, Lee SW, Kang EH, Lee YA, Choe JY, Lee EY, Sparks JA. Serum Biomarkers of Pulmonary Damage and Risk for Progression of Rheumatoid Arthritis-Associated Interstitial Lung Disease. J Rheumatol 2025 Jan 15: jrheum.2024-0713.
  • Chang, S. H., Jung, S., Chae, J. J., Kim, J. Y., Kim, S. U., Choi, J. Y., Han, H. J., Kim, H. T., Kim, H. J., Kim, H. J., Park, W. Y., Sparks, J. A., Lee, E. Y., & Lee, J. S. (2024). Therapeutic single-cell landscape: methotrexate exacerbates interstitial lung disease by compromising the stemness of alveolar epithelial cells under systemic inflammation. EBioMedicine, 2024 Oct:108:105339.
  • Yi K, Jo S, Song W, Lee HI, Kim HJ, Kang JH, Kim SU, Lee SH, Park J, Kim TH, Lee JS, Lee EY, Kim TJ.  Analysis of Singel-cell transcriptome and surface protein expression in ankylosing spondylitis identifies OX40-positive and glucocorticoid-induced tumor necrosis factor receptor-positive pathogenic Th17 cells. Arthritis Rheumatol. 2023 Jul;75(7):1176-1186. 
  • Park J, An H, Lim J, Park IS, Kim MH, Kim JH, Kim SW, Koh YI, Lee EY, Cheon JH. Interplay between chronic inflammation and clonal haematopoiesis of indeterminate potential in Behcet’s diasese. Arthritis Res Ther. 2023 Mar 2;25(1):33.
  • Chang SH, Lee JS, Ha YJ, Kim MU, Park CH, Lee JS, Kim JW, Chung SW, Pyo JY, Lee SW, Kang EH, Lee YA, Park YB, Choe JY, Lee EY. Lung function trajectory of rheumatoid arthritis-associated interstitial lung disease. Rheumatology (Oxford). 2023 Sep 1;62(9):3014-3024.
  • Bae S, Kim K, Kang K, Kim H, Lee M, Oh B, Kaneko K, Ma S, Choi JH, Kwak H, Lee EY, Park SH, Park-Min KH. RANKL-responsive epigenetic mechanism reprograms macrophages into bone-resorbing osteoclasts. Cell Mol Immunol. 2023 Jan;20(1):94-109. 
  • Kim JW, Chung SW, Pyo JY, Chang SH, Kim MU, Park CH, Lee JS, Lee JS, Ha YJ, Kang EH, Lee YA, Park YB, Lee EY, Choe JY; KORAIL cohort investigators. Methotrexate, leflunomide, and tacrolimus use and the progression of rheumatoid arthritis-associated interstitial lung disease. Rheumatology (Oxford). 2022 Nov 17:keac651. 
  • Kang J, Kim JY, Jung Y, Kim SU, Lee EY, Cho JY. Identification of Metabolic Signature Associated with Idiopathic Inflammatory Myopathy Reveals Polyamine Pathway Alteration in Muscle Tissue. Metabolites. 2022 Oct 21;12(10):1004. 
  • Jeong S, Choi S, Park SM, Kim J, Ghang B, Lee EY. Incident and recurrent herpes zoster for first-line bDMARD and tsDMARD users in seropositive rheumatoid arthritis patients: a nationwide cohort study. Arthritis Res Ther. 2022 Jul 28;24(1):180. 
  • Choi S, Ghang B, Jeong S, Choi D, Lee JS, Park SM, Lee EY. Association of first, second, and third-line bDMARDs and tsDMARD with drug survival among seropositive rheumatoid arthritis patients: Cohort study in A real world setting Semin Arthritis Rheum. 2021 Jun 7;51(4):685-691. 
  • Kim JS, Choi M, Choi JY, Kim JY, Kim JY, Song JS, Ivashkiv LB, Lee EY. Implication of the Association of Fibrinogen Citrullination and Osteoclastogenesis in Bone Destruction in Rheumatoid Arthritis. Cells. 2020 Dec 20;9(12):2720. 
  • Lee JS, An Y, Yoon CJ, Kim JY, Kim KH, Freeman AF, Yim JJ, Shin EC, Holland SM, Lee EY, Ju YS. Germline gain-of-function mutation of STAT1 rescued by somatic mosaicism in immune dysregulation-polyendocrinopathy-enteropathy-X-linked-like disorder. J Allergy Clin Immunol. 2020 Mar;145(3):1017-1021. 
  • Park JW, Kim HA, Shin K, Park YB, Kim TH, Song YW, Lee EY. Effects of tapering tumor necrosis factor inhibitor on the achievement of inactive disease in patients with axial spondyloarthritis: a nationwide cohort study. Arthritis Res Ther. 2019 Jul 4;21(1):163
  • Park JW, Kim MJ, Lee JS, Ha YJ, Park JK, Kang EH, Lee YJ, Song YW, Lee EY. Impact of Tumor Necrosis Factor Inhibitor Versus Nonsteroidal Antiinflammatory Drug Treatment on Radiographic Progression in Early Ankylosing Spondylitis: Its Relationship to Inflammation Control During Treatment. Arthritis Rheumatol. 2019 Jan;71(1):82-90. 
  • Choi IA, Choi JY, Jung S, Basri F, Park S, Lee EY. GV1001 immunotherapy ameliorates joint inflammation in a murine model of rheumatoid arthritis by modifying collagen-specific T-cell responses and downregulating antigen-presenting cells. Int Immunopharmacol. 2017 May;46:186-193.
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