*Publications: PI3Kγδ inhibitor plus radiation enhances the antitumor immune effect of PD-1 blockade in syngenic murine breast cancer and humanized patient-derived xenograft model. Min Guk Han, Bum-Sup Jang, Mi Hyun Kang, Deukchae Na, In Ah Kim. European Journal of Cancer 2021 in press PI3Kαδ inhibitor combined with radiation enhances the antitumor immune effect of anti-PD1 in a syngeneic murine triple negative breast cancer model. Jang WI, Han MK, Kang MH, Park JM, Kim EE, Bae JY, Ahn S, Kim IA. Int J Radiat Oncol Biol Phys 2021; 110(3):845-858 Tumor mutation burden, immune checkpoint crosstalk and radiosensitivity in single-cell RNA sequencing data of breast cancer. Jang BS, Han W, Kim IA. Radiother Oncol. 2020:142:202-209 A radiosensitivity gene signature and PD-L1 status predict clinical outcome of patients with glioblastoma multiforme in The Cancer Genome Atlas Dataset. Jang BS, Kim IA. Cancer Res Treat 2019:52(2):335-354 A radiosensitivity gene signature and PD-L1 predict the clinical outcomes of patients with lower grade glioma in TCGA. Jang BS, Kim IA. Radiother Oncol. 2018;128(2):245-253. Inhibition of PI4K IIIα radiosensitizes in human tumor xenograft and immune-competent syngeneic murine tumor model. Park Y, Park JM, Kim DH, Kwon J, Kim IA. Oncotarget 2017; 30;8(66):110392-110405 A radiosensitivity gene signature and PD-L1 status predict clinical outcome of patients with invasive breast carcinoma in The Cancer Genome Atlas (TCGA) dataset. Jang BS, Kim IA. Radiother Oncol 2017; 124:403-407 Targeting phosphatidylinositol 4-kinase IIIα for radiosensitization: a potential model of drug repositioning using anti-HCV agent. Kwon J, Kim DH, Park JM, Park YH, Hwang YH, Wu HG, Shin KH, Kim IA. Int J Radiat Oncol Biol Phys 2016; 96:867-876 MicroRNA-200c increases radiosensitivity of human cancer cells with activated EGFR-associated signaling. Koo T, Cho. BJ, Kim DH, Park JM, Choi EJ, Kim HH, Lee DJ and Kim IA. Oncotarget 2017;8(39): 65457-65468 Radiosensitizing effect of lapatinib in human epidermal growth factor receptor 2-positive breast cancer cells. Yu T, Cho BJ, Choi EJ, Park JM, Kim DH, Kim IA. Oncotarget 2016;7(48): 79089-79100 Inhibition of STAT3 enhances the radiosensitizing effect of temozolomide in glioblastoma cells in vitro and in vivo. Han TJ, Cho BJ, Choi EJ, Kim DH, Song SH, Paek SH, Kim IA. J Neurooncol. 2016;130(1):89-98 MicroRNA-203 modulates the radiation sensitivity of human malignant glioma cells. Chang JH, Hwang YH, Lee DJ, Kim DH, Park JM, Wu HG, Kim IA. Int J Radiat Oncol Biol Phys. 2016;94(2):412-20. Isotype-Specific Inhibition of Histone Deacetylases: Identification of Optimal Targets for Radiosensitization. Kim JH, Moon SH, No M, Kim JJ, Choi EJ, Cho BJ, Kim JS, Kim IH, Kim IA. Cancer Res Treat 2016;48(3):1130-40 The effect of chemoradiotherapy with SRC tyrosine kinase inhibitor, PP2 and Temozolomide on malignant glioma cells in vitro and in vivo. Eom KY, Cho BJ, Choi EJ, Kim JH, Chie EK, Wu HG, Kim IH, Paek SH, Kim JS, Kim IA. Cancer Res Treat 2016;48(2):687-97 Radiosensitization with combined use of olaparib and PI-103 in triple-negative breast cancer, Jang NY, Kim DH, Cho BJ, Choi EJ, Lee JS, Wu HG, Chie EK, Kim IA. BMC Cancer 2015;15:89 Enhanced cytotoxic effect of radiation and temozolomide in malignant glioma cells: targeting PI3K-AKT-mTOR signaling, HSP90 and histone deacetylases. Choi EJ, Cho BJ, Lee DJ, Hwang YH, Chun SH, Kim HH, Kim IA. BMC Cancer. 2014 ;13;14-17 MicroRNA-7 increases radiosensitivity of human cancer cells with activated EGFR-associated signaling. Lee KM, Choi EJ, Kim IA. Radiother Oncol 2011:101:171-6 HDAC inhibitor-mediated radiosensitization in human carcinoma cells: a general phenomenon? Kim IA, Kim IH, Kim HJ, Chie EK, Kim JS. J Radiat Res 2010;51(3):257-63 Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-RAS. Oh JS, Kim JJ, Byun JY, Kim IA. Int J Radiat Oncol Biol Phys 2010:76 (1):5-8 Potential prognostic value of heat-shock protein 90 in the presence of phosphatidylinositol-3-kinase overexpression or loss of PTEN, in invasive breast cancers. Song CH, Park SY, Eom KY, Kim JH, Kim SW, Kim JS, Kim IA. Breast Cancer Res 2010;12(2): R20 Targeting epidermal growth factor receptor–associated signaling pathways in non–small cell lung cancer cells: Implication in radiation response. Choi EJ, Ryu YK, Kim SY, Wu HK, Kim JS, Kim IH, Kim IA. Mol Cancer Res 2010; 8(7); 1027–36. Targeting HER2 signaling pathway for radiosensitization: Alternative strategy for therapeutic resistance. No M, Choi EJ, Kim IA. Cancer Biology & Therapy 2009: 8(24):2351-2361 Epigenetic modulation of radiation response in human cancer cells with activated EGFR or HER-2 signaling: Potential role of histone deacetylase 6. Kim IA, No M, Lee JM et al. Radiother Oncol 2009: 92:125-132 HDAC inhibitor-mediated radiosensitization of human cancer cells: Class differences and the potential influence of p53. Kim IA, Shin JH, Kim IH et al. Clin Cancer Res 2006;2(3): 1;12:940-9 *Patents Modulation of radiation response using microRNAs Composition for enhancing radiation sensitivity comprising PI4K isozyme inhibitor Method for treating triple negative breast cancer combined with radiotherapy comprising administering phosphatidylinositol 3-kinase inhibitor and PD-1 blockade