Overview
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Overview
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Laboratory Introduction
Laboratory Introduction
Laboratory of antibody engineering
Laboratory of antibody engineering
This is the research team of Professor Junho Jung. We are mainly conducting research related to antibody engineering. It consists of a research team of 4 post-doctoral fellows, 17 graduate students, and 1 scientist.
Related Researcher
Junho Chung Professor
- Email : jjhchung@snu.ac.kr
Research topics
We create novel therapeutic antibodies and biopharmaceuticals. An anti-hepatocyte growth factor (HGF)-neutralizing antibody (YYB101 OR NOV1105, nov.ncc.re.kr/eng/) is in phase II clinical trial (NCT04368507). A few more antibodies and CAR (chimeric antigen receptor) T cell therapies are under pre-clinical development and expected to enter clinical phase in 2021. We invent novel platform technologies in the field of bispecific antibodies, antibody drug conjugate (ADC) and CAR T cell therapy. Anti-cotinine antibody is now used for a new form of switchable CAR T cell therapy and ADC. We develop algorithms for deciphering B cell repertoire of human and animals using Machine learning and Next Generation Sequencing (NGS) technology. This research provides us valuable information on the immunological process of viral infection, autoimmune disease and carcinogenesis.
Research goals
The anti-hepatocyte growth factor antibody currently in phase 2 clinical trials, three antibody therapeutic candidates under preclinical development, and two CAR T cell therapeutics are striving to enter clinical trials as soon as possible. In addition, a number of antibody therapeutic candidates and antibody therapeutics development technologies are in the research stage.
Research achievements
Kim SI, Noh J, Kim S, Choi Y, Yoo DK, Lee Y, Lee H, Jung J, Kang CK, Song KH, Choe PG, Kim HB, Kim ES, Kim NJ, Seong MW, Park WB, Oh MD, Kwon S, Chung J. Stereotypic neutralizing VH antibodies against SARS-CoV-2 spike protein receptor binding domain in COVID-19 patients and healthy individuals. Sci Transl Med. 27 Jan 2021: Vol. 13, Issue 578, eabd6990 [Epub ahead of print] PubMed PMID: 33397677.
Chang S, Kim S, Han J, Ha S, Lee H, Song SW, Lee D, Kwon S, Chung J, Kim J. A High-Throughput Single-Clone Phage Fluorescence Microwell Immunoassay and Laser-Driven Clonal Retrieval System. Biomolecules. 2020 Mar 29;10(4). doi: 10.3390/biom10040517. PubMed PMID: 32235304; PubMed Central PMCID: PMC7226094.
Noh J, Kim O, Jung Y, Han H, Kim JE, Kim S, Lee S, Park J, Jung RH, Kim SI, Park J, Han J, Lee H, Yoo DK, Lee AC, Kwon E, Ryu T, Chung J, Kwon S. High-throughput retrieval of physical DNA for NGS-identifiable clones in phage display library. MAbs. 2019 Apr;11(3):532-545. doi: 10.1080/19420862.2019.1571878. Epub 2019 Feb 12. PubMed PMID: 30735467; PubMed Central PMCID: PMC6512904.
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