Overview
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Overview
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Laboratory Introduction
Laboratory Introduction
Molecular and Translational Neuroimaging Lab
Molecular and Translational Neuroimaging Lab
Our laboratory was established to research on brain tumor diagnosis and treatment images. Among others studying intermediate imaging for overall molecular imaging and clinical application of glioblastoma. The complex microenviroment of glioblastoma is classified through molecular MR images to verify the therapeutic efficacy of anticancer drugs and to study application using biocombinant materials and equipment for glioblastoma treatment. Under the guidance of Professor Seung-hong Choi, researchers are doing experimental design, performing and MRI imaging, and collaborating with laboratories in various fields to conduct joint research.
Related Researcher
Seung Hong Choi Professor
- Email : verocay1@snu.ac.kr
Research topics
We are focusing on the following research topics. - A study on the radioactive characteristics according to the immune phenotype in malignant encephalomas - Development of mouse tumor model and establishment of MRI protocol for drug delivery effectiveness determination - Validate tumor treatment effect in mouse tumor models - MRI verification of macrophages and CCL2 expression and nCBV correlation in glioblastoma. - Establishing a drug delivery system to control the microenvironment.
Research goals
In future studies, we will develop new biodegradable devices for selection of candidate materials to enhance glioblastoma diagnosis and treatment. We will study techniques to efficiently activate the treatment material.
Research achievements
Kang T, Cha GD, Park OK, Cho HR, Kim M, Lee J, Kim D, Lee B, Chu J, Koo S, Hyeon T, Kim DH, Choi SH. Penetrative and Sustained Drug Delivery Using Injectable Hydrogel Nanocomposites for Postsurgical Brain Tumor Treatment. ACS Nano. 2023 Mar 28;17(6):5435-5447.
Lee J, Cho HR, Cha GD, Seo H, Lee S, Park CK, Kim JW, Qiao S, Wang L, Kang D, Kang T, Ichikawa T, Kim J, Lee H, Lee W, Kim S, Lee ST, Lu N, Hyeon T, Choi SH, Kim DH. Flexible, sticky, and biodegradable wireless device for drug delivery to brain tumors. Nat Commun. 2019 Nov 15;10(1):5205.
Kim D, Kwon HJ, Shin K, Kim J, Yoo RE, Choi SH, Soh M, Kang T, Han SI, Hyeon T. Multiplexible Wash-Free Immunoassay Using Colloidal Assemblies of Magnetic and Photoluminescent Nanoparticles. ACS Nano. 2017 Aug 22;11(8):8448-8455.
Kim J, Cho HR, Jeon H, Kim D, Song C, Lee N, Choi SH, Hyeon T. Continuous O2-Evolving MnFe2O4 Nanoparticle-Anchored Mesoporous Silica Nanoparticles for Efficient Photodynamic Therapy in Hypoxic Cancer. J Am Chem Soc. 2017 Aug 16;139(32):10992-10995.
Lee H, Song C, Hong YS, Kim M, Cho HR, Kang T, Shin K, Choi SH, Hyeon T, Kim DH. Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module. Sci Adv. 2017 Mar 8;3(3):e1601314.
Kim K, Lee J, Park OK, Kim J, Kim J, Lee D, Paidi VK, Jung E, Lee HS, Lee B, Lee CW, Ko W, Lee K, Jung Y, Lee C, Lee N, Back S, Choi SH, Hyeon T. Geometric Tuning of Single-Atom FeN4 Sites via Edge-Generation Enhances Multi- Enzymatic Properties. Adv Mater. 2023 Feb 28:e2207666.
Koo S, Park OK, Kim J, Han SI, Yoo TY, Lee N, Kim YG, Kim H, Lim C, Bae JS, Yoo J, Kim D, Choi SH, Hyeon T. Enhanced Chemodynamic Therapy by Cu-Fe Peroxide Nanoparticles: Tumor Microenvironment-Mediated Synergistic Fenton Reaction. ACS Nano. 2022 Feb 22;16(2):2535-2545.
Cha GD, Lee WH, Sunwoo SH, Kang D, Kang T, Cho KW, Kim M, Park OK, Jung D, Lee J, Choi SH, Hyeon T, Kim DH. Multifunctional Injectable Hydrogel for In Vivo Diagnostic and Therapeutic Applications. ACS Nano. 2022 Jan 25; 16(1):554-567.
Lee Y, Kang T, Cho HR, Lee GJ, Park OK, Kim S, Lee B, Kim HM, Cha GD, Shin Y, Lee W, Kim M, Kim H, Song YM, Choi SH, Hyeon T, Kim DH. Localized Delivery of Theranostic Nanoparticles and High-Energy Photons using Microneedles-on- Bioelectronics. Adv Mater. 2021 Jun; 33(24):e2100425.
Lim C, Hong YJ, Jung J, Shin Y, Sunwoo SH, Baik S, Park OK, Choi SH, Hyeon T, Kim JH, Lee S, Kim DH. Tissue-like skin-device interface for wearable bioelectronics by using ultrasoft, mass-permeable, and low-impedance hydrogels. Sci Adv. 2021 May 7;7(19):eabd3716.
Lee J, Cho HR, Cha GD, Seo H, Lee S, Park CK, Kim JW, Qiao S, Wang L, Kang D, Kang T, Ichikawa T, Kim J, Lee H, Lee W, Kim S, Lee ST, Lu N, Hyeon T, Choi SH, Kim DH. Flexible, sticky, and biodegradable wireless device for drug delivery to brain tumors. Nat Commun. 2019 Nov 15;10(1):5205.
Kim D, Kwon HJ, Shin K, Kim J, Yoo RE, Choi SH, Soh M, Kang T, Han SI, Hyeon T. Multiplexible Wash-Free Immunoassay Using Colloidal Assemblies of Magnetic and Photoluminescent Nanoparticles. ACS Nano. 2017 Aug 22;11(8):8448-8455.
Kim J, Cho HR, Jeon H, Kim D, Song C, Lee N, Choi SH, Hyeon T. Continuous O2-Evolving MnFe2O4 Nanoparticle-Anchored Mesoporous Silica Nanoparticles for Efficient Photodynamic Therapy in Hypoxic Cancer. J Am Chem Soc. 2017 Aug 16;139(32):10992-10995.
Lee H, Song C, Hong YS, Kim M, Cho HR, Kang T, Shin K, Choi SH, Hyeon T, Kim DH. Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module. Sci Adv. 2017 Mar 8;3(3):e1601314.
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