Our laboratory conducts various translational researches to identify the etiologies of upper airway obstruction diseases and devise novel diagnostic and therapeutic modalities. Upper airway obstructive disease causes various forms of hypoxia. Obstructive Sleep apnea, a typical upper airway obstructive disease, is caused by the narrowing of the upper airway and repeated blockage of airflow, resulting in hypoxia. This occurs high blood pressure, diabetes, and metabolic syndrome. When the hypoxic condition is prolonged, it leads to cardiovascular and cerebrovascular complications, leading to death. In this laboratory, it has been conducted for searching a biomarker for the early diagnosis and effective follow-up of hypoxic exposure conditions including sleep apnea research excavations since 2009. Chronic rhinosinusitis with nasal polyps (CRSwNP) is also a common disease that obstructs the upper airway. Nasal polyps have many clinical difficulties due to their recalcitrance and recurrence. We are investigating the pathogenesis of CRS and nasal polyposis. Hypoxia is also known to be a major determinant of cancer metastasis, survival and differentiation of cancer stem cells. We are seeking new fundamental treatment methods for cancer by identifying microenvironmental factors that affect cancer progression in relation to hypoxia.