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Overview

Laboratory Introduction

Laboratory of Molecular Imaging and Therapy

Laboratory of Molecular Imaging and Therapy
This laboratory is a laboratory belonging to the Department of Nuclear Medicine, Seoul National University College of Medicine, and conducts research and development on diagnosis, treatment, and theranostics using molecular imaging. Since 1991, when this laboratory was first established, it has been internationally recognized in molecular imaging research by publishing approximately 700 SCI papers in leading academic journals. In the nuclear medicine department, professors, researchers, and students majoring in medicine, pharmacy, physics, chemistry, biology, and cognitive sciences collaborate in a multidisciplinary way using molecular imaging and nanotechnology. It is conducting advanced translational research to develop new diagnostic and therapies for diseases such as cancer, dementia, and immune-related diseases. In addition, it has been designated as the nuclear medicine and molecular imaging cooperation center in the field of nuclear medicine by the International Atomic Energy Agency (IAEA). We are conducting joint research with domestic and foreign researchers through various research tasks such as drug development and advanced radiopharmaceutical expansion, by introducing the latest research knowledge at domestic and international academic conferences.
Related Researcher
강건욱

Keon Wook Kang Professor

천기정

Gi Jeong Cheon Professor

윤혜원 

Hyewon Youn Professor

Research topics

By using small animal molecular imaging techniques such as PET/CT, SPECT/CT, and optical imaging equipments, our research focus on various disease-targeted imaging, cell/gene therapy imaging, nanomedicine, and theranosis. (1) Development of new anticancer therapy using macrophage polarization and targeted drug delivery (2) Development of tumor and its microenvironment target imaging/therapeutic methods using albumin, exosomes and various biodegradable nanoparticles (3) Development of theranostics probe for imaging of inflammatory and metabolic diseases (rheumatoid arthritis, neuroinflammation, obesity, brown fat, etc.) in mouse models (4) Enhancement of immunotherapeutic effect using the fibroblast active protein-targeted theranostic probe (5) Development of precision medicine using therapeutic radionuclides (6) Interaction of mitochondrial proteins on glucose analog uptake in tumor cells (7) Development of an optimized reporter with high sensitivity (8) Evaluation of vaccine efficacy using molecular imaging techniques

Research goals
Under the motto of 'harmony and cooperation, creativity and challenge, global leadership', we intend to contribute to the promotion of human health domestically and internationally by using radioactive isotopes for molecular imaging and therapeutics.
Research achievements
<대표논문>
1. Park CR, Jo JH, Song MG, Park JY, Kim YH, Youn H, Paek SH, Chung JK, Jeong JM, Lee YS, Kang KW*. Secreted protein acidic and rich in cysteine mediates active targeting of human serum albumin in U87MG xenograft mouse models. Theranostics. 2019 Oct 11;9(24):7447-7457.
2. Park JY, Song MG, Kim WH, Kim KW, Lodhi NA, Choi JY, Kim YJ, Kim JY, Chung H, Oh C, Lee YS, Kang KW*, Im HJ, Seok SH, Lee DS, Kim EE, Jeong JM. Versatile and Finely Tuned Albumin Nanoplatform based on Click Chemistry. Theranostics. 2019 May 18;9(12):3398-3409.
3. Suh M, Im HJ, Ryoo HG, Kang KW, Jeong JM, Kumar S, Ballal SS, Yadav MP, Bal C, Jeong CW, Kwak C, Cheon GJ*. Head to head comparison of 68Ga-NGUL and 68Ga-PSMA-11 in patients with metastatic prostate cancer: a prospective study. J Nucl Med 2021; 62:1457-1460.
4. Ryoo HG, Suh MS, Kang KW, Lee DW, Han SW, Cheon GJ*. Phase 1 study of no-carrier added (NCA) 177Lu-DOTATATE (SNU-KB-01) in patients with somatostatin receptor-positive neuroendocrine tumors: the first clinical trial of peptide receptor radionuclide therapy (PRRT) in Korea. Cancer Res Treat 2023; 55:334-343. 
5.  Suh M, Ryoo HG, Kang KW, Jeong JM, Jeong CW, Kwak C, Cheon GJ*. Phase I clinical trial of PSMA-targeting 68Ga-NGUL in healthy volunteers and patients with prostate cancer. Korean J Radiol 2022; 23:911-920.
6. Jung HN, Lee SY, Lee S, Youn H*, Im HJ. Lipid nanoparticles for delivery of RNA therapeutics: Current status and the role of in vivo imaging. Theranostics. 2022 Oct 24;12(17):7509-7531.
7.  Lee SY, Oh HR, Kim YH, Bae SH, Lee Y, Lee YS, Lee BC, Cheon GJ, Kang KW, Youn H*. Cerenkov luminescence imaging of interscapular brown adipose tissue using a TSPO-targeting PET probe in the UCP1 ThermoMouse. Theranostics. 2022 Aug 29;12(14):6380-6394.
8.  Lee SH, Denora N, Laquintana V, Mangiatordi GF, Lopedota A, Lopalco A, Cutrignelli A, Franco M, Delre P, Song IH, Kim HW, Kim SB, Park HS, Kim K, Lee SY, Youn H*, Lee BC, Kim SE. Radiosynthesis and characterization of [18F]BS224: a next-generation TSPO PET ligand insensitive to the rs6971 polymorphism. Eur J Nucl Med Mol Imaging. 2021 Dec;49(1):110-124.
<대표특허>
1. 이윤상, 강건욱, 정재민, 이동수, 정준기, 송명근, 김우형, 박지용. 알부민 기반 질환 추적 진단 또는 치료 나노플랫폼. 서울대학교 산학협력단, 대한민국, 10-1879682 (2018.7.12)
2. 이윤상, 이윤식, 정대홍, 이동수, 정재민, 강건욱, 박지용, 정신영. 항체 작용화 방법 및 나노입자-항체 결합 나노플랫폼의 제조 방법. 서울대학교 산학협력단, 대한민국, 10-1919427B1 (2018.11.16)
3. 김상은, 이병철, 윤혜원, 최지영, 정재호, 송인호. 약물 전달과 내재화 효율이 강화된 약물복합체. BIK Therapeutics/분당서울대병원/서울대병원, 대한민국, 10-2250737(2021.5.4), 10-2362265 (2022.2.8), 10-2443219 (2022,9,7)
4. 윤혜원 (Hyewon Youn). 염기서열 최적화된 나트륨-요오드 수송체 유전자 및 그 용도 (Codon optimized sodium-iodide symporter gene and it use), 서울대학교 산학협력단, 대한민국10-1389088(2014.4.18), 미국 US09096867 (2015.8.4)
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