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Overview

Laboratory Introduction

Neurosurgical Laboratory of Brain Tumor

Neurosurgical Laboratory of Brain Tumor
The main fields of clinical interest are stereotactic functional neurosurgeries, including Deep brain stimulation, brain tumors, and gamma knife radiosurgery. The laboratory's main interests are in the development of new anticancer drugs and potential therapeutics for various brain diseases, as well as research on tumor development, malignant transformation of brain tumors, and cell biology of neural stem cells.
Related Researcher
백선하

Sun Ha Paek Professor

Research topics

A large part of our research is in the aggregation and banking of thousands of brain tumor tissues received in the operating room to discover early diagnostic and progression markers of tumor development and tumor progression that are correlated with the clinical information of brain tumor patients. In order to study the genomics of brain tumors using Next Generation Sequencin and single cell RNA sequencing, we are conducting primary cell culture of various brain tumors. In addition, research is underway to investigate the fundamental mechanisms in the development of brain tumors using primary cell cultures of various brain tumors.

Research goals
We aim to faithfully deliver results by continuing our ongoing research.
Research achievements
  1. Song CW, Kim H, Cho H, Kim MS, Paek SH, Park HJ, Griffin RJ, Terezakis S, Cho LC. HIF-1α Inhibition Improves Anti-Tumor Immunity and Promotes the Efficacy of Stereotactic Ablative Radiotherapy (SABR). Cancers (Basel). 2022 Jul 4;14(13):3273.

    Varn FS, Johnson KC, Martinek J, Huse JT, Nasrallah MP, Wesseling P, Cooper LAD, Malta TM, Wade TE, Sabedot TS, Brat D, Gould PV, Wöehrer A, Aldape K, Ismail A, Sivajothi SK, Barthel FP, Kim H, Kocakavuk E, Ahmed N, White K, Datta I, Moon HE, Pollock S, Goldfarb C, Lee GH, Garofano L, Anderson KJ, Nehar-Belaid D, Barnholtz-Sloan JS, Bakas S, Byrne AT, D'Angelo F, Gan HK, Khasraw M, Migliozzi S, Ormond DR, Paek SH, Van Meir EG, Walenkamp AME, Watts C, Weiss T, Weller M, Palucka K, Stead LF, Poisson LM, Noushmehr H, Iavarone A, Verhaak RGW; GLASS Consortium. Glioma progression is shaped by genetic evolution and microenvironment interactions. Cell. 2022 May 24:S0092-8674(22)00536-0.

    Jeong JY, Park H, Yoo H, Kim EJ, Jeon B, Lee JD, Kang D, Lee CJ, Paek SH, Roh EJ, Yi GS, Kang SS. Trifluoperazine and Its Analog Suppressed the Tumorigenicity of Non-Small Cell Lung Cancer Cell; Applicability of Antipsychotic Drugs to Lung Cancer Treatment. Biomedicines. 2022 Apr 30;10(5):1046.

    Jeon H, Lee H, Kwon DH, Kim J, Tanaka-Yamamoto K, Yook JS, Feng L, Park HR, Lim YH, Cho ZH, Paek SH, Kim J. Topographic connectivity and cellular profiling reveal detailed input pathways and functionally distinct cell types in the subthalamic nucleus. Cell Rep. 2022 Mar 1;38(9):110439.

    Kwon T, Ra JS, Lee S, Baek IJ, Khim KW, Lee EA, Song EK, Otarbayev D, Jung W, Park YH, Wie M, Bae J, Cheng H, Park JH, Kim N, Seo Y, Yun S, Kim HE, Moon HE, Paek SH, Park TJ, Park YU, Rhee H, Choi JH, Cho SW, Myung K. Precision targeting tumor cells using cancer-specific InDel mutations with CRISPR-Cas9. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2103532119.

    Kwon DH, Paek SH, Kim YB, Lee H, Cho ZH. In vivo 3D Reconstruction of the Human Pallidothalamic and Nigrothalamic Pathways With Super-Resolution 7T MR Track Density Imaging and Fiber Tractography. Front Neuroanat. 2021 Oct 27;15:739576.

    Jo A, Lee Y, Kam TI, Kang SU, Neifert S, Karuppagounder SS, Khang R, Kang H, Park H, Chou SC, Oh S, Jiang H, Swing DA, Ham S, Pirooznia S, Umanah GKE, Mao X, Kumar M, Ko HS, Kang HC, Lee BD, Lee YI, Andrabi SA, Park CH, Lee JY, Kim H, Kim H, Kim H, Cho JW, Paek SH, Na CH, Tessarollo L, Dawson VL, Dawson TM, Shin JH. PARIS farnesylation prevents neurodegeneration in models of Parkinson's disease. Sci Transl Med. 2021 Jul 28;13(604):eaax8891.

    Shin HY, Han KS, Park HW, Hong YH, Kim Y, Moon HE, Park KW, Park HR, Lee CJ, Lee K, Kim SJ, Heo MS, Park SH, Kim DG, Paek SH. Tumor Spheroids of an Aggressive Form of Central Neurocytoma Have Transit-Amplifying Progenitor Characteristics with Enhanced EGFR and Tumor Stem Cell Signaling. Exp Neurobiol. 2021 Apr 30;30(2):120-143. (Corresponding)

    Lee SJ, Choi YJ, Kim HI, Moon HE, Paek SH, Kim TY, Ko SG. Platycodin D inhibits autophagy and increases glioblastoma cell death via LDLR upregulation. Mol Oncol. 2021 May 1.

    Park K, Park KH, Park HR, Lee JM, Kim YH, Kim DY, Won TB, Kong SH, Kim JH, Shin CS, Paek SH. Long-term Outcome of Microscopic Transsphenoidal Surgery for Prolactinomas as an Alternative to Dopamine Agonists. J Korean Med Sci. 2021 Apr 19;36(15):e97. (Corresponding)

    Kim A, Kim HJ, Kim A, Kim Y, Jang M, Paek SH, Jeon B. Bilateral subthalamic nucleus deep brain stimulation is an effective treatment for diphasic dyskinesia. Eur J Neurol. 2021 Jan 29. (Co-corresponding)

    Park KH, Sun S, Lim YH, Park HR, Lee JM, Park K, Jeon B, Park HP, Kim HC, Paek SH. Clinical outcome prediction from analysis of microelectrode recordings using deep learning in subthalamic deep brain stimulation for Parkinson`s disease. PLoS One. 2021 Jan 26;16(1):e0244133. (Co-corresponding)

    Kim Y, Varn FS, Park SH, Yoon BW, Park HR, Lee C, Verhaak RGW, Paek SH. Perspective of mesenchymal transformation in glioblastoma. Acta Neuropathol Commun. 2021 Mar 24;9(1):50.

    Yang J, Moon HE, Park HW, McDowell A, Shin TS, Jee YK, Kym S, Paek SH, Kim YK. Brain tumor diagnostic model and dietary effect based on extracellular vesicle microbiome data in serum. Exp Mol Med. 2020 Sep;52(9):1602-1613.

    Park HW, Park CG, Park M, Lee SH, Park HR, Lim J, Paek SH, Choy YB. Intrastriatal administration of coenzyme Q10 enhances neuroprotection in a Parkinson's disease rat model. Sci Rep. 2020 Jun 12;10(1):9572.

    Shih DJH, Nayyar N, Bihun I, Dagogo-Jack I, Gill CM, Aquilanti E, Bertalan M, Kaplan A, D'Andrea MR, Chukwueke U, Ippen FM, Alvarez-Breckenridge C, Camarda ND, Lastrapes M, McCabe D, Kuter B, Kaufman B, Strickland MR, Martinez-Gutierrez JC, Nagabhushan D, De Sauvage M, White MD, Castro BA, Hoang K, Kaneb A, Batchelor ED, Paek SH, Park SH, Martinez-Lage M, Berghoff AS, Merrill P, Gerstner ER, Batchelor TT, Frosch MP, Frazier RP, Borger DR, Iafrate AJ, Johnson BE, Santagata S, Preusser M, Cahill DP, Carter SL, Brastianos PK. Genomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma. Nat Genet. 2020 Apr;52(4):371-377.

    Han S, Kim S, Chen Z, Shin HK, Lee SY, Moon HE, Paek SH, Park S. 3D Bioprinted Vascularized Tumour for Drug Testing. Int J Mol Sci. 2020 Apr 23;21(8):2993

    Kim BH, Lee H, Park CG, Jeong AJ, Lee SH, Noh KH, Park JB, Lee CG, Paek SH, Kim H, Ye SK. STAT3 Inhibitor ODZ10117 Suppresses Glioblastoma Malignancy and Prolongs Survival in a Glioblastoma Xenograft Model. Cells. 2020 Mar 15;9(3):722.

    Heo JY, Nam MH, Yoon HH, Kim J, Hwang YJ, Won W, Woo DH, Lee JA, Park HJ, Jo S, Lee MJ, Kim S, Shim JE, Jang DP, Kim KI, Huh SH, Jeong JY, Kowall NW, Lee J, Im H, Park JH, Jang BK, Park KD, Lee HJ, Shin H, Cho IJ, Hwang EM, Kim Y, Kim HY, Oh SJ, Lee SE, Paek SH, Yoon JH, Jin BK, Kweon GR, Shim I, Hwang O, Ryu H, Jeon SR, Lee CJ. Aberrant Tonic Inhibition of Dopaminergic Neuronal Activity Causes Motor Symptoms in Animal Models of Parkinson's Disease. Curr Biol 2020 Jan 20;30(2):276-291.

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