Overview
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Overview
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Laboratory Introduction
Laboratory Introduction
Laboratory for Immune Tolerance & Transplantation immunology
Laboratory for Immune Tolerance & Transplantation immunology
In recent years, there is growing interest in the clinical therapeutic effects of anti-cancer drugs using immune checkpoint inhibitors and CAR-T cells in the immuno-oncology field. Many studies have focused on the mechanisms. Especially, elucidating immune avoidance mechanisms in the tumor microenvironment and developing targets is essential to overcome the limitation of immune-oncology drugs. Our laboratory intensively investigates the mechanism of immune rejection in both allografts and xenografts using animal models, tissues, cells, and molecule levels to identify immune activation and tolerance mechanisms. On the contrary, we are looking for a way to regulate immune avoidance mechanisms in tumor microenvironments for a therapeutic approach. To overcome the limitations of immune checkpoint inhibitors and CAR-T cell therapy, we are developing immune checkpoint activators that can convert cold tumors into hot tumors.
Related Researcher
Chunggyu Park Professor
- Email : chgpark@snu.ac.kr
Research topics
(1) Development of antibody therapy as an immune checkpoint activator. (2) Using high throughput immune profiling system (CyTOF, scRNA sequencing) to analyze the immune evasion mechanisms in tumor microenvironment. (3) Development of human immune checkpoint molecule expressing mouse model. (4) Using the human immune checkpoint molecule expressing mouse model to test the effect of immune checkpoint activators.
Research goals
Our research goal is to analyze the immune evasion mechanisms in the tumor microenvironment by using high throughput immune profiling system and develop the immune checkpoint activator as an anti-cancer therapy to overcome the limitations of immunological anti-cancer drugs.
Research achievements
Lim, Y., Kang, S. J., Cho, B. K., Kim, H. J., Mun, J. H., Roh, M. R., Gulati, N., Yang, H. J., Moon, J. H., Won, C. H., & Park, C. G.(2022).Intra-tumoral heterogeneity and immune escape of melanoma arising from congenital melanocytic nevus revealed by spatial gene expression profiling. Journal of the European Academy of Dermatology and Venereology,36(12), e1044-e1047.
Nguyen-Phuong, T., Chung, H., Jang, J., Kim, J. S., & Park, C. G.(2022).Acetyl-CoA carboxylase-1/2 blockade locks dendritic cells in the semimature state associated with FA deprivation by favoring FAO. Journal of Leukocyte Biology,111(3), 539-551.
Kim, J. M., Hong, S. H., Shin, J. S., Min, B. H., Kim, H. J., Chung, H., Kim, J., Bang, Y. J., Seo, S., Hwang, E. S., Kang, H. J., Ha, J., & Park, C. G.(2021).Long-term control of diabetes in a nonhuman primate by two separate transplantations of porcine adult islets under immunosuppression. American Journal of Transplantation,21(11), 3561-3572.
Kim, J. M., Hong, S. H., Chung, H., Shin, J. S., Min, B. H., Kim, H. J., Kim, J., Hwang, E. S., Kang, H. J., Ha, J., & Park, C. G.(2021).Long-term porcine islet graft survival in diabetic non-human primates treated with clinically available immune suppressants. Xenotransplantation,28(2), [e12659].
Chung, H., Nam, H., Nguyen-Phuong, T., Jang, J., Hong, S. J., Choi, S. W., Park, S. B., & Park, C. G.(2021).The blockade of cytoplasmic HMGB1 modulates the autophagy/apoptosis checkpoint in stressed islet beta cells. Biochemical and Biophysical Research Communications,534, 1053-1058
Chang, S. H., Kim, H. J., & Park, C. G.(2020).Allogeneic ADSCs Induce the Production of Alloreactive Memory-CD8 T Cells through HLA-ABC Antigens.Cells,9(5).
Lee, S. J., Kim, H. J., Byun, N. R., & Park, C. G.(2020).Donor-Specific Regulatory T Cell-Mediated Immune Tolerance in an Intrahepatic Murine Allogeneic Islet Transplantation Model with Short-Term Anti-CD154 mAb Single Treatment. Cell transplantation, 29.
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