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Laboratory Introduction

Laboratory of Radiation Oncology & Radiation Biology

Laboratory of Radiation Oncology & Radiation Biology
Since Professor Sung-Hwan Ha established the Laboratroy of Radiation Oncology and Radiation Biology in 1987, our aim has been to optimise radiation therapy; maintaining maximal treatment efficacy whilst minimising damage to normal tissues. Our research encompasses both basic radiation biology and mediation research, with recent projects including studies on the role of radiation biology therapy in the treatment non-tumour diseases such as cardiac arrhythmia and arthritis. We are a multi-disciplinary team consisting of Pf. Hong-Gyun Woo, Pf. Hak-Jae Kim, Pf. Ji-Hyun Chang, Pf. Joo-ho Lee, Pf. Byung-Hyunck Kim, Dr. Sun-Hwa Lee and Mr. Sang-Rok Jeon.
Related Researcher
우홍균

Hong Gyun Wu Professor

이주호

Joo Ho Lee Professor

김학재

Hak Jae Kim Professor

Research topics

) Maximising the efficacy of radiatio therapy  To study the mechanisms behind paradoxical cell death via the EGF pathway  To develop a model of glioblastoma in order to stduy the mechnisms involved in the recurrence of diseases  To develop novel drugs to maximise the effeicacy of radiation therapy on refractory brain tumours  Comparision of the anticancer responses and oncological characteristic of a natural versas an radiation-induced sarcoma cell line 2) Overcoming complications following radiation therapy  To study pathogenesis of radiation-induced esophagitis and to develop novel therapy using EGF  To study the mechanisms behind radiation-induced enteritis, changes in the gut microbiota and treatment with probiotics  To develop novel treatments for radiation-induced neurotoxicity 3) Non-tumour diseases and fundamental dadiation biology research  To develop novel cardiac arrhythmia treatment using high-energy radiation  Genome analysis of radiation-induced inflammation and immunoreaction and its relationship with radiation-induced sarcoma  Pre-clinical study of low-dose radiation therapy for osteoarthritis

Research goals
Our Goals include both continuing to research the optimisation of radiation therapy in existing fields, such as refractroy cancer, but also expanding our research into novel fields such as 'FLASH' and the treatment of non-tumour diseases including cardiac arrhythmia and arthritis. Through this research, we aim to nurture the next-generation of researchers in the field of radiation biology.
Research achievements
Identification of Genes Involved in EGF-induced Apoptosis Using CRISPR/Cas9 Knockout Screening: Implications for Novel Therapeutic Targets in EGFR-Overexpressing Cancers. Kim JS, Lee JH et al. Cancer Res Treat. 2023

Chemoradiation in Patients with Rectal Cancer. Jang BS, Chang JH, Chie EK, Kim K, Park JW, Kim MJ, Song EJ, Nam YD, Kang SW, Jeong SY, Kim HJ. Int J Radiat Oncol Biol Phys. 2020

Heart substructural dosimetric parameters and risk of cardiac events after definitive chemoradiotherapy for stage III non-small cell lung cancer. Jang BS, Cha MJ, Kim HJ, Oh S, Wu HG, Kim E, et al. Radiother Oncol. 2020

Gut Microbiome Composition Is Associated with a Pathologic Response After Preoperative Chemoradiation in Patients with Rectal Cancer. Jang BS, Chang JH, Chie EK, Kim K, Park JW, Kim MJ, et al. Int J Radiat Oncol Biol Phys. 2020

Identification of FES as a Novel Radiosensitizing Target in Human Cancers. Kim BH, Kim YJ, Kim MH, Na YR, Jung D, Seok SH, Kim J, Kim HJ. Clin Cancer Res. 2020

RadiosensitizationofGlioblastomaCellsbyaNovelDNAMethyltransferase-inhibitingPhthalimido- Alkanamide Derivative.WeeCW,Kim JH, Kim HJ, Kang HC, SuhSY,Shin BS, Ma E, Kim IH. Anticancer Res. 2019

A phthalimidoalkanamide derived novel DNMT inhibitor enhanced radiosensitivity of A549 cells by inhibition of homologous recombination of DNA damage. Kang HC, Chie EK, Kim HJ, Kim JH, Kim IH, Kim K, Shin BS, Ma E. Invest New Drugs. 2019

Disulfiram, a Re-positioned Aldehyde Dehydrogenase Inhibitor, Enhances Radiosensitivity of Human Glioblastoma Cells In Vitro. Koh HK, Seo SY, Kim JH, Kim HJ, Chie EK, Kim SK, Kim IH. Cancer Res Treat. 2019

Differential effect of GLUT1 overexpression on survival and tumor immune microenvironment of human papilloma virus type 16-positive and -negative cervical cancer. Kim BH, Chang JH. Sci Rep. 2019

Human glioblastoma arises from subventricular zone cells with low-level driver mutations. Lee JH, Lee JE et al. Nature. 2018
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