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Laboratory Introduction

Laboratory of Molecular Chronic Infectious Disease

Laboratory of Molecular Chronic Infectious Disease
Our laboratory is researching about the pathogenic mechanism of pathogens that cause chronic infection such as HBV, HIV, Mycobacterium tuberculosis and nontuberculous mycobacteria in regard to type 1 interferon signaling. We are also developing new medicine and vaccine for pathogens. In addition we try to develop anti-cancer immunotherapy, adjuvant, therapeutic DNA vaccine platform taking advantage of mutant strains, strain diversity, genetic mutation derived from our research.
Related Researcher
김범준

Bum-Joon Kim Professor

Research topics

1) Development of anti-cancer immunotherapy using novel species Mycobacterium paragordonae isolated in this lab 2) Development of anti-cancer immunotherapy using recombinant BCG and Mycobacterium smegmatis producing human cytokines 3) Development of SARS-CoV2 vaccine using recombinant Mycobacterium paragordonae 4) Development of anti-cancer immunotherapy using HBV-derived peptide that induces type 1 interferon from dendritic cells 5) Development of live vaccine for prevention and treatment for tuberculosis using Mycobacterium paragordonae 6) Research about pathogenesis and therapeutic vaccine of HBV genotype C focusing on type 1 interferon signaling 7) Research about pathogenesis and therapy of Mycobacterium abscessus focusing on type 1 interferon signaling

Research goals
Our laboratory is purposing development of anti-cancer immunotherapy, tuberculosis live vaccine and HBV therapeutic vaccine taking advantage of mutant strains, strain diversity, genetic mutation derived from our research about pathogenesis of chronic infection
Research achievements
1. Heat-killed Mycobacterium paragordonae therapy exerts an anti-cancer immune response via enhanced immune cell mediated oncolytic activity in xenograft mice model. Lee, S. Y., Yang, S. B., Choi, Y. M., Oh, S. J., Kim, B. J., Kook, Y. H. & Kim, B. J., 1 Mar 2020, In : Cancer Letters. 472, p. 142-150 9 p.
2. A Telomerase-Derived Peptide Exerts an Anti-Hepatitis B Virus Effect via Mitochondrial DNA Stress-Dependent Type I Interferon Production. Choi, Y. M., Kim, H., Lee, S. A., Lee, S. Y. & Kim, B. J., 21 May 2020, In : Frontiers in Immunology. 11, 652.
3. Mycobacterium abscessus infection leads to enhanced production of type 1 interferon and NLRP3 inflammasome activation in murine macrophages via mitochondrial oxidative stress. Kim, B. R., Kim, B. J., Kook, Y. H. & Kim, B. J., 2020, In : PLoS pathogens. 16, 3, e1008294.
4. Potential of recombinant Mycobacterium paragordonae expressing HIV-1 Gag as a prime vaccine for HIV-1 infection. Kim, B. J., Kim, B. R., Kook, Y. H. & Kim, B. J., 1 Dec 2019, In : Scientific Reports. 9, 1, 15515.
5. Phagosome escape of rough Mycobacterium abscessus strains in murine macrophage via phagosomal rupture can lead to type I interferon production and their cell-to-cell spread. Kim, B. R., Kim, B. J., Kook, Y. H. & Kim, B. J., 2019, In : Frontiers in Immunology. 10, JAN, 125.
6. rt269I Type of Hepatitis B Virus (HBV) Leads to HBV e Antigen Negative Infections and Liver Disease Progression via Mitochondrial Stress Mediated Type I Interferon Production in Chronic Patients With Genotype C Infections. Lee, S. Y., Choi, Y. M., Oh, S. J., Yang, S. B., Lee, J. H., Choe, W. H., Kook, Y. H. & Kim, B. J., 2019, In : Frontiers in Immunology. 10, p. 1735 1 p.
7. Male-specific hepatitis B virus large surface protein variant W4P potentiates tumorigenicity and induces gender disparity. Lee, S. A., Kim, H., Won, Y. S., Seok, S. H., Na, Y. R., Shin, H. B., Inn, K. S. & Kim, B-J., 3 Feb 2015, In : Molecular Cancer. 14, 1, 23.
8. Tumor-suppressive effect of a telomerase-derived peptide by inhibiting hypoxia-induced HIF-1α-VEGF signaling axis. Kim, B. K., Kim, B. R., Lee, H. J., Lee, S. A., Kim, B. J., Kim, H., Won, Y. S., Shon, W. J., Lee, N. R., Inn, K. S. & Kim, B. J., Mar 2014, In : Biomaterials. 35, 9, p. 2924-2933 10 p.5.
9. Tumor-suppressive effect of a telomerase-derived peptide by inhibiting hypoxia-induced HIF-1α-VEGF signaling axis. Kim, B. K., Kim, B. R., Lee, H. J., Lee, S. A., Kim, B. J., Kim, H., Won, Y. S., Shon, W. J., Lee, N. R., Inn, K. S. & Kim, B. J., Mar 2014, In : Biomaterials. 35,
10. Nucleotide change of codon 182 in the surface gene of hepatitis B virus genotype C leading to truncated surface protein is associated with progression of liver diseases. Lee, S. A., Kim, K., Kim, H. & Kim, B. J., Jan 2012, In : Journal of Hepatology. 56, 1, p. 63-69 7 p.
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