암연구소 특강

제목 : Tumour suppressor mechanisms in the control of chromosome stability
연자 : Ashok R. Venkitaraman <University of Cambridge, UK>
일시 : 2013.5.15(수) 16시
장소 : 암연구소 2층 이건희홀

Chromosomes serve as the functional and physical containers for the information encoded in the human genome. Instability in their structure and number is a hallmark of human epithelial cancers, which occurs early during carcinogenesis. What provokes chromosomal instability, and how it fosters cancer pathogenesis, remain major unresolved questions central to understanding carcinogenesis. Moreover, the near-universal occurrence of chromosomal instability in common epithelial malignancies offers important opportunities for devising new approaches to cancer therapy. I will discuss insights into these issues that come from our studies on the macromolecular interactions that control DNA replication, repair and mitotic progression, the key cancer suppressor mechanisms that maintain chromosome stability in normal cells. To understand these processes at resolutions ranging from molecules to organisms, we have used an integrative and interdisciplinary approach, combining somatic cell genetics, protein biochemistry, single-molecule biophysics, chemical biology and transgenic models.